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Dr. Antonio Ledo, Castellana 167, E-28046, Madrid (Spain) Syringoma is a common benign tumor of eccrine sweat gland origin which usually appears around the eyelids. Eruptive syringoma is a rare variant of syringoma that appears in successive crops on anterior surfaces of the trunk, neck and arms. We present a patient with eruptive syringoma who showed a satisfactory response to therapy with topical tretinoin. Case Report A 23-year-old woman reported a 10-year history of asymptomatic papular lesions located on anterior surfaces of her neck, trunk and arms. Lesions appeared on these areas in successive crops. No other symptoms were present. Physical examination revealed multiple rounded red to brown papules ranging in size from 1 to 5 mm on the anterior surfaces of her neck, trunk and arms (fig. la) and in a smaller number on her flanks and dorsum. A skin biopsy specimen showed, embedded in a fibrous stroma, small ducts, the walls of which were lined by two rows of epithelial cells, and independent strands of basophilic epithelial cells. The lumina of the ducts contained an amorphous material. The diagnosis of eruptive syringoma was established, and treatment with 0.05% tretinoin cream (magistral formulation) once daily was started. The concentration was then progressively increased from 0.05 to 0.1%, in the same excipient (oil-in-water cream). After 4 months, the lesions in the treated areas were flattened and skin-colored (fig. la, b), with a good tolerance. On untreated areas, new lesions went on appearing. Discussion Syringomas are benign appendageal tumors, originating on the intraepidermal eccrine ducts, that appear as small firm papules, redto brown-colored and ranging in size from 1 to 10 mm [1,2]. They occur predominantly in women and may develop at any age, with a peak incidence between the third and fourth decades, although they are not rare in children [3]. The most frequent clinical variant is the one located on the infraocu-lar areas in healthy people, but other clinical